京都大学医学部附属病院 緩和医療科

研究について

研究について研究実績

【論文】

【2025年】

  • Amano K, Okamura S, Miura T, Baracos VE, Mori N, Sakaguchi T, Uneno Y, Ishiki H, Hiratsuka Y, Yokomichi N, Hamano J, Baba M, Mori M, Morita T. Clinical Implications of the C-Reactive Protein-Albumin Ratio as a Prognostic Marker in Terminally Ill Patients with Cancer. J Palliat Med. 2025. doi: 10.1089/jpm.2024.0471.
  • Kondo Y, Ohashi S, Katada C, Nakai Y, Yamamoto Y, Tamaoki M, Kikuchi O, Yamada A, Hirohashi K, Mitani Y, Kataoka S, Saito T, Vu THN, Kondo T, Uneno Y, Sunami T, Yokoyama A, Matsubara J, Matsuda T, Naganuma S, Oryu K, Flashner S, Shimonosono M, Nakagawa H, Muto M. Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization. Gastroenterol. 2025;60(5):546-560. doi: 10.1007/s00535-024-02210-y.
  • Sagawa M, Matsui R, Sano A, Sakai M, Hiraoka S, Tabei I, Imai T, Matsumoto H, Onogawa S, Sonoi N, Nagata S, Ogawa R, Wakiyama S, Miyazaki Y, Kumagai K, Tsutsumi R, Okabayashi T, Uneno Y, Higashibeppu N, Kotani J. Perioperative or combined preoperative and postoperative standard nutrition therapy for patients with head and neck or gastrointestinal cancer: A systematic review and meta-analysis. Clin Nutr ESPEN. 2025 ;67:567-577. doi: 10.1016/j.clnesp.2025.03.170.

【2024年】

  • Takenouchi S, Uneno Y, Matsumoto S, Chikada A, Uozumi R, Izawa T, Ouchi S, Kuroda T, Hidaka Y, Tanimukai H, Nomura M, Muto M, Tamura K, Tsuneto S, Kizawa Y, Morita T, Mori M. Culturally Adapted RN-MD Collaborative SICP-Based ACP: Feasibility RCT in Advanced Cancer Patients. J Pain Symptom Manage. 2024;68(6):548-560.e2.
  • Uneno Y, Kotera Y, Kikuchi K, Yamada M, Sugitani M, Terado S, Maehara H, Sakamoto Y, Sugao S, Tani H, Shimizu A, Kubo Y, Fujisawa D, Muto M. Self-compassion-based online group psychotherapy for bereavement-related grief: The COMPACT feasibility trial. Gen Hosp Psychiatry. 2024;90:116-123.
  • Uneno Y, Mori M, Saito J, Otsuki A, Kuchiba A, Sakurai N, Nakaya N, Fujimori M, Shimazu T; INFORM Study 2023 Group. Awareness, information sources, and beliefs regarding palliative care in the general population in Japan: a nationwide cross-sectional survey (INFORM study 2023). Jpn J Clin Oncol. 2024;54(11):1171-1179.
  • Matsumoto H, Onogawa S, Sonoi N, Sagawa M, Wakiyama S, Ogawa R, Miyazaki Y, Nagata S, Okabayashi T, Tazuma S, Futamura A, Uneno Y, Higashibeppu N, Kotani J. Dietary intervention for adult survivors of cancers other than breast cancer: A systematic review. Medicine (Baltimore). 2024;103(26):e38675.
  • Matsui R, Sagawa M, Sano A, Sakai M, Hiraoka SI, Tabei I, Imai T, Matsumoto H, Onogawa S, Sonoi N, Nagata S, Ogawa R, Wakiyama S, Miyazaki Y, Kumagai K, Tsutsumi R, Okabayashi T, Uneno Y, Higashibeppu N, Kotani J. Impact of Perioperative Immunonutrition on Postoperative Outcomes for Patients Undergoing Head and Neck or Gastrointestinal Cancer Surgeries: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ann Surg. 2024;279(3):419-428.
  • Yu Uneno, Nomura M, Hosokai T, Kurakake Y, Fuki M, Shiomi H, Takeuchi Y, Tamaoki M, Yokoyama A, Katada C, Muto M. Successful Management of Malignant Pericarditis using Nivolumab for Metastatic Esophageal Squamous Cell Carcinoma: A Case Report. Intern Med. 2024;63(5):677-680.
  • Yu Uneno, Keita Fukuyama, Ayumi Nishimura, Kana Eguchi, Hideki Kojima, Takeshi Umino, Kikuko Miyazaki, Eiju Negora, Keiko Minashi, Osamu Sugiyama, Taichi Shimazu, Manabu Muto, Shigemi Matsumoto. Barriers and Facilitators to the Implementation of an Electronic Patient-Reported Outcome System at Cancer Hospitals in Japan. Cureus 2024;16(4): e58611.
  • Amano K, Okamura S, Baracos V, Mori N, Sakaguchi T, Uneno Y, Hiratsuka Y, Hamano J, Miura T, Ishiki H, Yokomichi N, Hatano Y, Morita T, Mori M; East-Asian collaborative cross-cultural Study to Elucidate the Dying process (EASED) investigators. Fluid retention and weight loss in refractory cancer cachexia. BMJ Support Palliat Care. 2024:spcare-2024-004820.
  • Amano K, Okamura S, Baracos VE, Mori N, Sakaguchi T, Uneno Y, Hiratsuka Y, Hamano J, Miura T, Ishiki H, Yokomichi N, Hatano Y, Morita T, Mori M; East-Asian collaborative cross-cultural Study to Elucidate the Dying process (EASED) investigators. Impacts of fluid retention on prognostic abilities of cachexia diagnostic criteria in cancer patients with refractory cachexia. Clin Nutr ESPEN. 2024;60:373-381.
  • Kyuragi Y, Oishi N, Hatakoshi M, Hirano J, Noda T, Yoshihara Y, Ito Y, Igarashi H, Miyata J, Takahashi K, Kamiya K, Matsumoto J, Okada T, Fushimi Y, Nakagome K, Mimura M, Murai T, Suwa T; Segmentation and Volume Estimation of the Habenula Using Deep Learning in Patients With Depression. Biological Psychiatry Global Open Science. 2024 Apr 3;4(4):100314.
  • Ishikawa Y, Oishi N, Kyuragi Y, Hatakoshi M, Hirano J, Noda T, Yoshihara Y, Ito Y, Miyata J, Nemoto K, Fujita Y, Igarashi H, Takahashi K, Murakami S, Kanno H, Izumi Y, Takamiya A, Matsumoto J, Kodaka F, Nakagome K, Mimura M, Murai T, Suwa T; Electroconvulsive therapy-specific volume changes in nuclei of the amygdala and their relationship to long-term anxiety improvement in depression..Mol Psychiatry. 2024 Dec 16.

【2023年】

  • Shimada K, Tsuneto S. Novel method for predicting nonvisible symptoms using machine learning in cancer palliative care. Sci Rep. 2023;13(1):12088.
  • Kondo M, Kihira T, Sakaguchi Y, Shimada K, Shirai Y, Tamura K. Growth Experience Bereaved of a Spouse by Cancer: Relying on Merleau-Ponty’s Reorganization of the Body Schemes. Omega (Westport). 2023:302228231164859.
  • Yukiko Watanabe, Natsuki Kawashima, Yu Uneno, Soichiro Okamoto, Manabu Muto, Tatsuya Morita. Determinants of Attitude Toward End-of-Life Care Among Junior Physicians: Findings from a Nationwide Survey in Japan. Palliat Med Rep. 2023;4(1):257-263.
  • Yu Uneno, Tatsuya Morita, Yukiko Watanabe, Soichiro Okamoto, Natsuki Kawashima, Manabu Muto. Letter to the Editor: Respecting Patient Autonomy, End-of-Life Care Experience, and the Transitional Status. J Palliat Med. 2023;26(5):609-610.
  • Lucie-May Golbourn, Rory Colman, Yu Uneno, Yasuhiro Kotera. A Need for Grounded Mental Health Interventions to Reduce Cancer Stigma. SN Comprehensive Clinical Medicine 2023;5(114).
  • Ueshima J, Nagano A, Maeda K, Enomoto Y, Kumagai K, Tsutsumi R, Higashibeppu N, Uneno Y, Kotani J; JAPANESE SOCIETY FOR CLINICAL NUTRITION AND METABOLISM Guideline Development Committee. Nutritional counseling for patients with incurable cancer: Systematic review and meta-analysis. Clin Nutr. 2023;42(2):227-234.

【2022年】

  • Yu Uneno, Yasuhiro Kotera, Daisuke Fujisawa, Yuki Kataoka, Kazuhiro Kosugi, Nanami Murata, Takaomi Kessoku, Akihiko Ozaki, Hirotomo Miyatake, Manabu Muto. Development of a novel COMPAssion focused online psyChoTherapy for bereaved informal caregivers: the COMPACT feasibility trial protocol. BMJ Open 2022;12(12):e067187
  • Takaomi Kessoku, Yu Uneno, Yuka Urushibara-Miyachi, Kiyofumi Oya, Akihiko Kusakabe, Atsushi Nakajima, Noritoshi Kobayashi, Yasushi Ichikawa, Mitsunori Miyashita, Manabu Muto, Masanori Mori, Tatsuya Morita. Development of a list of competencies and entrustable professional activities for resident physicians during death pronouncement: a modified Delphi study. BMC Med Educ. 2022 ;22(1):119.
  • Naosuke Yokomichi, Kengo Imai, Masaki Sakamoto, Masashi Horiki, Toshihiro Yamauchi, Satoru Miwa, Satoshi Inoue, Yu Uneno, Hidekazu Suzuki, Toru Wada, Yuri Ichikawa, Tatsuya Morita. Feasibility of a fast-track randomized controlled trial of cell-free and concentrated ascites reinfusion therapy for patients with refractory malignant ascites. BMC Cancer. 2022;22(1):218.
  • Tomoo Ikari, Yusuke Hiratsuka, Shao-Yi Cheng, Mitsunori Miyashita, Tatsuya Morita, Masanori Mori, Yu Uneno, Koji Amano, Yuko Uehara, Takashi Yamaguchi, Isseki Maeda, Akira Inoue. Factors associated with good death of patients with advanced cancer: a prospective study in Japan. Support Care Cancer. 2022;30(11):9577-9586.
  • Uneno Y, Imura H, Makuuchi Y, Tochitani K, Watanabe N. Pre-emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer. Cochrane Database Syst Rev. 2022;11(11):CD013604.
  • Soichiro Okamoto, Yu Uneno, Natsuki Kawashima, Shunsuke Oyamada, Yusuke Hiratsuka, Keita Tagami, Manabu Muto, Tatsuya Morita. Difficulties Facing Junior Physicians and Solutions Toward Delivering End-of-Life Care for Patients with Cancer: A Nationwide Survey in Japan. Palliat Med Rep. 2022;3(1):255-263.
  • Yu Uneno, Maki Iwai, Naoto Morikawa, Keita Tagami, Yoko Matsumoto, Junko Nozato, Takaomi Kessoku, Tatsunori Shimoi, Miyuki Yoshida, Aya Miyoshi, Ikuko Sugiyama, Kazuhiro Mantani, Mai Itagaki, Akemi Yamagishi, Tatsuya Morita, Akira Inoue, Manabu Muto. Development of a national health policy logic model to accelerate the integration of oncology and palliative care: a nationwide Delphi survey in Japan. Int J Clin Oncol. 2022;27(9):1529-1542
  • Hirotomo Miyatake, Akihiko Ozaki, Yasuhiro Kotera, Ryo Sakamoto, Divya Bhandari, Yu Uneno, Hiroyuki Beniya. Case report on the legal assurance of Advance Care Planning in collective culture. Clin Case Rep. 2022;10(4):e05759.
  • Yusuke Hiratsuka, Mitsunori Miyashita, Yu Uneno, Kiyohumi Oya, Soichiro Okamoto, Takaomi Kessoku, Hironori Mawatari, Shunsuke Oyamada, Junko Nozato, Keita Tagami, Akira Inoue. Development and Validation of the Death Pronouncement Burden Scale for Oncology Practice. Palliat Med Rep. 2022;3(1):39-46.
  • Kengo Imai, Tatsuya Morita, Naosuke Yokomichi, Masanori Mori, Akemi Shirado Naito, Toshihiro Yamauchi, Hiroaki Tsukuura, Yu Uneno, Satoru Tsuneto, Satoshi Inoue. Association of the RASS Score with Intensity of Symptoms, Discomfort, and Communication Capacity in Terminally Ill Cancer Patients Receiving Palliative Sedation: Is RASS an Appropriate Outcome Measure? Palliat Med Rep. 2022;3(1):47-54.
  • Sayuri Yokota, Koji Amano, Shunsuke Oyamada, Hiroto Ishiki, Isseki Maeda, Tomofumi Miura, Yutaka Hatano, Yu Uneno, Tetsuo Hori, Yosuke Matsuda, Hiroyuki Kohara, Kozue Suzuki, Tatsuya Morita, Masanori Mori, on behalf of the East-Asian collaborative cross-cultural Study to Elucidate the Dying process (EASED) investigators. Effects of artificial nutrition and hydration on survival in patients with head and neck cancer and esophageal cancer admitted to palliative care units. Clinical Nutrition Open Science. 2022; 41: 33-43.

【2021年】

  • Kihara A, Shimada K, Tsuneto S. How Do We Taper and Discontinue Opioids in Cancer Patients? Considerations from the Activities of a Palliative Care Team at a University Hospital. Palliat Med Rep. 2021;2(1):255-259.
  • Tomoo Ikari, Yusuke Hiratsuka, Takuhiro Yamaguchi, Isseki Maeda, Masanori Mori, Yu Uneno, Tomohiko Taniyama, Yosuke Matsuda, Kiyofumi Oya, Keita Tagami, Akira Inoue. “3-Day Surprise Question” to predict prognosis of advanced cancer patients with impending death: Multicenter prospective observational study. Cancer Med. 2021;10(3):1018-1026.
  • Hiraku Tsujimoto, Yuki Kataoka, Yukihito Sato, Masahiro Banno, Emi Tsujino-Tsujimoto, Yukiyoshi Sumi, Ryuichi Sada, Takashi Fujiwara, Yoichi Ohtake, Junji Kumasawa, Haruki Imura, Yoshinobu Matsuda, Ryuhei So, Tomoko Kagawa, Takashi Yoshioka, Yu Uneno, Hiroyuki Nagano, Mai Akazawa , Takunori Hozumi, Yasushi Tsujimoto. A model six-month workshop for developing systematic review protocols at teaching hospitals: action research and scholarly productivity. BMC Med Educ. 2021;21(1):98.
  • Satoko Ito, Tatsuya Morita, Yu Uneno, Tomohiko Taniyama, Yosuke Matsuda, Hiroyuki Kohara, Isseki Maeda, Takeo Nakayama, Masanori Mori 3, EASED Investigators. Incidence and associated factors of sudden unexpected death in advanced cancer patients: A multicenter prospective cohort study. Cancer Med. 2021;10(14):4939-4947.
  • Tomoo Ikari, Yusuke Hiratsuka, Takuhiro Yamaguchi, Masanori Mori, Yu Uneno, Tomohiko Taniyama, Yosuke Matsuda, Kiyofumi Oya, Koji Amano, Keita Tagami, Akira Inoue. Is the 1-day surprise question a useful screening tool for predicting prognosis in patients with advanced cancer?-a multicenter prospective observational study. Ann Palliat Med. 2021;10(11):11278-11287.

【2020年】

  • Uneno Y, Sato K, Morita T, Nishimura M, Ito S, Mori M, Shimizu C, Horie Y, Hirakawa M, Nakajima TE, Tsuneto S, Muto M. Current status of integrating oncology and palliative care in Japan: a nationwide survey. BMC Palliat Care. 2020;19(1):12.
  • Uneno Y, Imura H, Makuuchi Y, Tochitani K, Watanabe N. Pre-emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer (Protocol). Cochrane Database of Systematic Reviews 2020, Issue 5. Art. No.: CD013604.

【2019年】

  • Mori M, Fujimori M, Ishiki H, Nishi T, Hamano J, Otani H, Uneno Y, Oba A, Morita T, Uchitomi Y. The Effects of Adding Reassurance Statements: Cancer Patients’ Preferences for Phrases in End-of-Life Discussions. J Pain Symptom Manage. 2019;57(6):1121-1129.
  • Mori M, Fujimori M, Ishiki H, Nishi T, Hamano J, Otani H, Uneno Y, Oba A, Morita T, Uchitomi Y.Adding a Wider Range and “Hope for the Best, and Prepare for the Worst” Statement: Preferences of Patients with Cancer for Prognostic Communication. Oncologist. 2019 ;24(9):e943-e952.

【2018年】

  • Fujii Y, Nishikawa Y, Nomura M, Miyamoto S, Uneno Y, Horimatsu T, Muto M. Readministration of Nivolumab after Persistent Immune-related Colitis in a Patient with Recurrent Melanoma. Intern Med. 2018;57(8):1173-1176.
  • 2. Uneno Y, Muto M, Morita T. Integration of oncology and palliative care: less-mentioned issues and a Japanese perspective. Lancet Oncol. 2018; 19(11):e570-571

【2017年】

  • Nishikawa Y, Kanai M, Narahara M, Tamon A, Brown JB, Taneishi K, Nakatsui M, Okamoto K, Uneno Y, Yamaguchi D, Tomono T, Mori Y, Matsumoto S, Okuno Y, Muto M.Association between UGT1A1*28*28 genotype and lung cancer in the Japanese population. Int J Clin Oncol. 2017;22(2):269-273.
  • Aizawa R, Matsumoto S, Uneno Y, Nishikawa Y, Ozaki Y, Mori Y, Kanai M, Ishida Y, Sakanaka K, Hiraoka M, Muto M. Severe esophagitis associated with cytomegalovirus during concurrent chemoradiotherapy for esophageal cancer. Jpn J Clin Oncol. 2017;47(9):885-888
  • Uneno Y, Taneishi K, Kanai M, Okamoto K, Yamamoto Y, Yoshioka A, Hiramoto S, Nozaki A, Nishikawa Y, Yamaguchi D, Tomono T, Nakatsui M, Baba M, Morita T, Matsumoto S, Kuroda T, Okuno Y, Muto M. Development and validation of a set of six adaptable prognosis prediction (SAP) models based on time-series real-world big data analysis for patients with cancer receiving chemotherapy: A multicenter case crossover study. PLoS One. 2017 Aug 24;12(8):e0183291

【2015年】

  • Yu Uneno, Akira Yokoyama, Yoshitaka Nishikawa, Taro Funakoshi, Yoshinao Ozaki, Ikuo Aoyama, Kiichiro Baba, Daisuke Yamaguchi, Shuko Morita, Yukiko Mori, Masashi Kanai, Hisanori Kinoshita, Takeshi Inoue, Nobukatsu Sawamoto, Riki Matsumoto, Shigemi Matsumoto, Manabu Muto. Paraneoplastic limbic encephalitis in human epidermal growth factor receptor-2-positive gastric cancer patient treated with trastuzumab-combined chemotherapy: case report and literature review. Intern Med. 2016;55(18):2605-9

【2013年】

  • Takahashi T, Serada S, Ako M, Fujimoto M, Miyazaki Y, Nakatsuka R, Ikezoe T, Yokoyama A, Taguchi T, Shimada K, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Mori M, Doki Y, Naka T, Nishida T. New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis. Int J Cancer. 2013;133(11):2737-43.
  • Shimada K, Serada S, Fujimoto M, Nomura S, Nakatsuka R, Harada E, Iwahori K, Tachibana I, Takahashi T, Kumanogoh A, Kishimoto T, Naka T. Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells. Cancer Sci. 2013;104(11):1483-91.
  • Hirata H, Tetsumoto S, Kijima T, Kida H, Kumagai T, Takahashi R, Otani Y, Inoue K, Kuhara H, Shimada K, Nagatomo I, Takeda Y, Goya S, Yoshizaki K, Kawase I, Tachibana I, Kishimoto T, Kumanogoh A. Favorable responses to tocilizumab in two patients with cancer-related cachexia. J Pain Symptom Manage. 2013;46(2):e9-e13.
  • Iwahori K, Serada S, Fujimoto M, Ripley B, Nomura S, Mizuguchi H, Shimada K, Takahashi T, Kawase I, Kishimoto T, Naka T. SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma. Int J Cancer. 2013;132(2):459-71.

【2011年】

  • Kijima T, Takeuchi K, Tetsumoto S, Shimada K, Takahashi R, Hirata H, Nagatomo I, Hoshino S, Takeda Y, Kida H, Goya S, Tachibana I, Kawase I. Favorable response to crizotinib in three patients with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion-type oncogene-positive non-small cell lung cancer. Cancer Sci. 2011;102(8):1602-4.